Sleutelwoord Insanity

James Cole is 'n gevangene van die toekoms wat na die verlede reis om die oorsprong van 'n virus wat die mensdom verwoes het, uit te vind. In sy soektog ontmoet hy 'n psigiater, Kathryn Railly, en 'n kranklike, Jeffrey Goines, wat moontlik verband hou met die raaiselagtige "Twaalf Aap-leër", die vermeende oorsaak van die pandemie. Cole moet die gevare van 'n onbekende wêreld en die raaisels van sy eie brein trotseer terwyl hy probeer om die toekoms te red voordat dit te laat is.

After causing a major incident, police officer Daigo Agawa takes his wife and daughter to live in the remote mountain village of Kuge. It seems the perfect place to recover from the ordeal, despite the mysterious disappearance of a previous officer posted there. One day, the body of an old woman is found on the mountain. The Goto family says she was attacked by a bear, but Daigo notices a human bite mark. It soon becomes clear that not all is as it seems in the village.

Ruthless siblings Roderick and Madeline Usher have built Fortunato Pharmaceuticals into an empire of wealth, privilege and power. But past secrets come to light when the heirs to the Usher dynasty start dying at the hands of a mysterious woman from their youth.