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Dr. Nancy was a program on MSNBC hosted by Dr. Nancy Snyderman. It aired weekdays at noon Eastern Time. The show launched on June 29, 2009, as part of a sweeping revamp of MSNBC's daytime weekday programs along with Morning Meeting with Dylan Ratigan, a revamp of the channel's graphics, and its launch in high definition. Topics on the show generally related to health and/or politics. Monica Novotny served as breaking news anchor during the show. On December 23, 2009, MSNBC announced that it cancelled the program due to low ratings. Its final broadcast appeared on December 17, 2009.

Now with Alex Wagner is a political opinion program on MSNBC presented by progressive host Alex Wagner. The show debuted on November 14, 2011 and airs on weekdays at noon ET.

In 2002, Phil Donahue returned to television to host a show called Donahue on MSNBC. Its debut Nielsen ratings were strong, but its audience evaporated over the following months. In late August 2002, it got one of the lowest possible ratings, less than MSNBC's average for the day of 0.2. On February 25, 2003, MSNBC cancelled the show, citing low viewership. However, that month, Donahue averaged 446,000 viewers and became the highest rated show on the network. Other MSNBC shows, including Hardball with Chris Matthews and Scarborough Country, averaged lower ratings in 2005. Later, the website AllYourTV.com reported it had received a copy of an internal NBC memo that mentioned that Donahue had to be fired because he would be a "difficult public face for NBC in a time of war". Donahue was a vocal critic of the 2003 Invasion of Iraq. He mentioned the internal memo later in an interview on WILL-AM, a public radio station. Keith Olbermann, arguably the network's most prominent commentator since Donahue, told TV Guide in 2007 that the cancellation had as much to do with the show's production cost as it did with political orientation. Despite the show's cancellation, Donahue's willingness to dissent played a critical role in getting The Oprah Winfrey Show to rejoin the anti-war movement in November 2002. In September 2002, Winfrey praised Donahue saying "the bottom line is we need you, Phil, because we need to be challenged by the voice of dissent".

Edgewise is an hour-long television news magazine program that aired on MSNBC from 1996 to 1997. The show was hosted by John Hockenberry. The show aired on Saturday evenings. In one notable episode with David Brinkley, the journalist was critical of President Bill Clinton. In July 1997, it was reported the show would be canceled. It ran until Labor Day of that year.

The News with Brian Williams, first shown on July 15, 1996, was the former flagship signature news broadcast on both MSNBC and CNBC. The show's host was Brian Williams. The News was a broadcast designed mainly for primetime viewers who might have missed that night's NBC Nightly News. The News was originally shown at 9pm ET on MSNBC until July 6, 2001. It was moved to the 8pm time slot on July 9, 2001. During the United States presidential election, 2000, The News was the main program for MSNBC's coverage. John Seigenthaler often substituted for Williams during his absence, mainly because of Williams' duties as substitute on NBC Nightly News with Tom Brokaw.

Jesse Ventura's America was a news talk show hosted by Jesse Ventura on MSNBC from October to December 2003. The show was broadcast once a week, on Saturdays, unlike many MSNBC shows which are on five nights a week. At the time of its airing, Jesse Ventura's America was the only national television show filmed in Minnesota. Among his guests were Charles Barkley, Gray Davis, Arianna Huffington, Rob Kampia, and Kathy McKee. However, the show was short-lived and ended on December 26, 2003, only a couple of months after the show began. Ventura later claimed that the show was cancelled because of his opposition to the Iraq War.

Tucker is an American television program on MSNBC that focused on politics, hosted by Tucker Carlson. The show aired from June 6, 2005–March 14, 2008.

Remember This? was a game show that tested contestants' knowledge of facts behind NBC News headlines. The series aired on MSNBC on Fridays, Saturdays, and Sundays from October 25, 1996 to October 5, 1997. Today Show weatherman Al Roker hosted the program, his first game show. Sande Stewart and Robert Mayer were executive producers. Remember This? was MSNBC's only game show.

Melissa Harris-Perry is a current affairs and political commentary television program on MSNBC hosted by American author and academic Melissa Harris-Perry. The program airs in the morning on weekends. Harris-Perry had been a frequent contributor and guest host for the network until it was announced that she will host a program of her own. The eponymous show debuted on February 18, 2012. She remains a professor at Tulane University and commutes to New York City on the weekends to host the show.

First Look is an American morning news program airing on MSNBC. It is broadcast live Monday through Friday mornings at 5 a.m. Eastern Time, and competes with CNN's Early Start and Fox News Channel's Fox & Friends First. The program is currently anchored by Mara Schiavocampo.

Imus in the Morning is an American radio show hosted by Don Imus on Cumulus Media Networks, and simulcast for television on Fox Business Network. The show originated locally on WNBC radio in New York City in December 1971. In October 1988 the show moved to WFAN when that radio station took over WNBC's dial position following an ownership change. It was later syndicated to 60 other stations across the country by Westwood One, a division of CBS Radio, airing weekdays from 5:30 to 10 am Eastern time. Beginning September 3, 1996, the 6 to 9 am portion was simulcast on the cable television network MSNBC. The show had been broadcast almost every weekday morning for 25 years on radio and 11 years on MSNBC until it was canceled on April 12, 2007 due to controversial comments made on the April 4, 2007 broadcast. The remark resulted in the program's cancellation the following week. The Imus in the Morning program returned to the morning drive on New York radio station WABC on December 3, 2007. WABC is the flagship station of ABC Radio Networks, which syndicates the show nationally. From 2007 to August 2009, the show was simulcast on television nationwide on RFD-TV and rebroadcast each evening on RFD HD in high-definition. After Imus and RFD reached a mutual agreement to prematurely terminate the five-year deal, Fox Business Network began simulcasting the program on October 5, 2009.

Rita Cosby: Live and Direct is a news/talk program which aired nightly on MSNBC. Hosted by Rita Cosby, Rita Cosby: Live and Direct consisted of breaking news reports and rare interviews. It largely emphasized getting the big stories and exclusives. Airing Monday through Thursday at 10pm ET, it also replayed in late night, at 1 a.m. ET. It originally aired at 9pm ET, and in that timeslot was the network's highest-rated program. Later, it switched time-slots with Scarborough Country a few months before it was canceled. Cosby’s shows originated from key areas around the globe, including from New Orleans and the Gulf Coast region to report on Hurricanes Katrina and Rita, as well as from Afghanistan and along the extensive US-Mexico border. The show's final air date was July 7, 2006. Cosby continued at the network as a lead host and senior correspondent until leaving in April 2007.

1600 Pennsylvania Avenue was an MSNBC television program hosted by David Shuster that ended in 2009. The show is a panel show based around the discussion of news and trends in American politics among the panelists and anchor. It is a continuation of the show, Race for the White House, which was originally hosted by David Gregory and aired in the same time slot from March to November 2008. Shuster became the host of the show when Gregory became moderator of NBC's Meet the Press. The show had a rotating array of panelists, but Eugene Robinson, Michael Smerconish, Richard Wolffe, and Pat Buchanan had appeared on a frequent basis. Race for the White House and 1600 Pennsylvania Avenue aired nightly at 6 PM Eastern on MSNBC.

Your Business is a small business oriented program on MSNBC, hosted by JJ Ramberg.

Scarborough Country was an opinion/analysis show broadcast on MSNBC Monday - Thursday at 9 P.M. ET. It was hosted by former congressman Joe Scarborough. Scarborough Country made its debut in April 2003. On average, Scarborough Country received approximately 300,000 viewers per night. Frequent on-air contributors to Scarborough Country were Craig Crawford, Pat Buchanan, Brent Bozell, and Tony Perkins. While remaining "extraordinarily conservative", Scarborough became more critical of President George W. Bush and some of his policies before it ended in 2007. Scarborough more frequently agreed with traditional conservative Pat Buchanan, who appeared on Scarborough's show nearly every day. Scarborough Country was replaced with Live with Dan Abrams in 2007 when Scarborough left to host Morning Joe.

Mississippi Rising - The Concert in Support of the Hurricane Katrina Recovery Efforts telethon was quickly put together after Hurricane Katrina had devastated the Gulf Coast of the United States between August 23–30, 2005. This three hour concert and telethon was broadcast live on MSNBC throughout North America on October 1, 2005. It was marketed commercially as a 2 DVD set in very limited numbers. All proceeds have gone to the Mississippi Hurricane Recovery Fund.

Verdict with Dan Abrams was a newscast on MSNBC, hosted by former MSNBC general manager Dan Abrams. It aired Monday-Friday at 9 p.m. Eastern.

The Abrams Report was an American television program on MSNBC, focusing on legal and tabloid issues. Until June 2006, the show was hosted by Dan Abrams. Following his appointment to General Manager of MSNBC, the show was anchored by guest hosts including Susan Filan and Lisa Daniels. In his farewell address on the show, Abrams said that the show would soon be replaced. Susan Filan served as a guest host on July 7, 2006. On July 10, 2006, Tucker with Tucker Carlson premiered in the 4pm ET and 6pm ET time-slots previously held by The Abrams Report.