Mis juhtub, kui su parimate kavatsuste tagajärjed tulevad tagasi sind jahtima? Ethan Hunt ja tema IMF-i tiim leiavad end pärast rängalt ebaõnnestunud missiooni olukorrast, mis ei allu enam nende kontrollile. Kuigi Ethan mõistab, et tema emotsioonidega manipuleeritakse, peab ta ajaga võidu joostes lõpuni minema ning valima, kas päästa oma pere ja sõbrad või miljonid teised, keda ähvardab globaalne oht.
Washingtoni bürokraadid otsustavad, et nende nägemusel seni peamiselt kaost tekitanud IMF (Impossible Mission Force) tuleb likvideerida ning selle agendid laiali saata. Samal ajal jõuab IMF-i tippagent Ethan Hunt (Tom Cruise) aga jälile Sündikaadile – IMF-i vastandile kuritegelikus allmaailmas. Ethan ja tema tiim astuvad nüüd vastu nende seni kõige võimatumale missioonile: ise põranda all olles sõdivad nad Sündikaadi ning selle tabamatute võtmeisikutega, pannes mängu kõik, mis neil on.
Tema Majesteedi salateenistuse parim agent Lorraine Broughton on osav spioon, kel ei jää vajaka ka sensuaalsusest ja metsikusest, ning kes on valmis oma oskusi võimatul missioonil ellu jäämiseks ära kasutama. Ta saadetakse kokkuvarisemise äärel Berliinist hindamatut toimikut ära tooma. Sealse osakonnajuhi David Percivali näol leiab ta partneri, kes aitab tal eluohtlikest spioonimängudest võitjana välja tulla.
The Lupin Collection, a vast ensemble of dangerous items acquired by the legendary gentleman thief Arsène Lupin, is stolen by an interdimensional crime syndicate known as the Ganglars. However, they receive opposition from two Super Sentai teams: the Lupinrangers, who aim to steal back the collection to live up their namesake's reputation and save those they have lost, and the Patrangers, who are tasked with upholding justice by retrieving the collection and taking down the Gangler.
Nikita is a drug-addicted juvenile delinquent who was accused of killing a police officer in cold blood during an attempted robbery of a pharmacy. She is later arrested and sentenced to death by lethal injection, upon which she was secretly drugged by the government, faking her death. Nikita is then "recruited" by a secret government organization and transformed into a highly skilled assassin who cannot be traced.
Near the end of the Vietnam War, a spy who was embedded in the South Vietnam army flees to the United States and takes up residence in a refugee community, where he continues to gather intelligence and report back to the Viet Cong.
Sydney Bristow, an agent who has been tricked to believe she is working for the U.S. government, is actually working for a criminal organization named the Alliance of Twelve. Upon learning this, Sydney becomes a double agent for the real CIA.
Carl Hamilton has just returned to Sweden after many years of secret education in the US when Stockholm is shaken by a series of terrorist attacks. Hamilton is assigned to assist the Swedish intelligence service in their pursuit of the guilty, but at the same time works as a double agent.
