Universitetsprofessor Dexter snubler inn på en politistasjon for å anmelde et mord. Sitt eget. Han ble forgiftet 24 timer tidligere og har nå kun kort tid igjen å leve. Nyinnspilling av film noir-klassikeren "D.O.A." fra 1950.
Family man Joe Petrus is living the American dream with his fiancé and step-kids. However, unbeknownst to them, Joe was involved in a mysterious crime three years ago and now his dangerous past is about to catch up with him. When a killer starts targeting the crew behind the crime, Joe realizes it's only a matter of time before his family is targeted. He returns to London to track down his old gang and find out who is coming after them.
